Transparency data: Non-tech summaries 2016: projects on immune disorders

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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of translational applied research – human immune disorders.

  • development of hiv-1 vaccines (hiv-1 vaccine, mice, immune responses)

  • autophagy in the hematopoietic system (autophagy (self-eating), leukemia, autoimmunity, ageing immunity, vaccination)

  • immunity, tolerance & treatments in type 1 diabetes (immunology, type 1 diabetes, infection, autoimmunity)

  • immune regulation, autoimmunity and infection (autoimmunity infection disease prognosis)

  • evaluation of antibody therapy in immune models (monoclonal antibody, immune therapy, inflammation)

  • coagulation proteins in inflammation and immunity (inflammation, thrombin, immunity, atheroma)

  • mechanisms for immunological memory and tolerance (T cell memory, regulatory T cell, autoimmunity, allergy)

  • macrophage biology in rodents and livestock (macrophage, Csf1, Csf1r)

  • development of the neonatal immune system and links with disease (immune system, neonatal, disease)

  • antibodies for research and clinical purposes (monoclonal antibodies)

  • production of antibodies (monoclonal, polyclonal anti-sera)

  • service monoclonal and polyclonal antibody production for biological & biomedical research (polyclonal and monoclonal antibody production)

  • immune mechanistic models of auto-immune disease (immune, mechanistic, adoptive transfer, inflammation)

  • animal models of autoimmune disease (autoimmune, disease, transplantation)

  • mechanistic models of immuno-oncology (cancer, immunology)

  • analysis of thymus development and function (thymus, tolerance, autoimmunity, development)

  • induction, maintenance, and regulation of type 2 immunity (helminth, infection, allergy, tolerance, T cell)

  • tuning the immune response in tuberculosis (tuberculosis, immune response, macrophage, zebrafish)

  • non-invasive mucosal immunisation (vaccines, non-invasive, safety, efficacy, mucosal)

  • regulation of autoimmunity in models of RA and SLE (rheumatoid arthritis, systemic lupus erythematosus)

  • immune responses in transplantation therapies (transplantation therapy, immunology, regenerative medicine)

  • testing of ES-62-based anti-inflammatory drugs (ageing; allergy; autoimmunity; drug development; parasitic worm)

  • modelling and therapeutics for autoimmune disease (autoimmune disease, gene therapy, adenovirus vector, autoimmune polyglandular syndrome type 1, intrathymic injection)

  • transplantation of regenerative cellular therapies (transplantation, stem cells, function, safety, immunogenicity)

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