Transparency data: Non-tech summaries 2016: projects on musculoskeletal disorders

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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of translational applied research – human musculoskeletal disorders.

  • enhancement of bone repair and bone ingrowth (bone, biocompatibility, repair, ingrowth)

  • mechanisms of skeletal repair and pain (fractures, bone, joint, pain)

  • joint tissue remodelling in health and arthritis (arthritis cartilage joint ageing)

  • cell-matrix interaction in health and disease (integrin, basement membrane, regeneration, stem cell)

  • new treatments for heterotopic ossification (heterotopic ossification, trauma, treatment, bone)

  • therapy of rheumatoid arthritis (rheumatoid arthritis, treatment, animal models)

  • models and therapy for congenital myasthenia (myasthenia, NMJ, AChR, DOK7, beta2-agonists)

  • cartilage repair using circulating stem cells (cartilage progenitor)

  • mechanisms and treatments of craniofacial birth defects (craniosynostosis, cleft palate, FGF, crouzon, craniofacial)

  • cell-extracellular matrix interactions and diseases (liver, tendon, extracellular matrix, fibrosis)

  • chorioallantoic membrane model for tissue engineering (chorioallantoic, skeletal, angiogenesis, tissue, engineering)

  • non-coding genes in osteoarthritis and musculoskeletal ageing (snoRNAs, osteoarthritis, ageing, murine, cartilage)

  • controlling osteoarthritis progression (osteoarthritis, ageing, trauma, mouse)

  • assessing biomaterial and cell transplant strategies for bone formation (biomaterials, scaffold degradation, bone formation, stem cells)

  • developing drugs to treat myotonic dystrophy (myotonic dystrophy, drugs screen, animal model)

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