Transparency data: Non-tech summaries 2016: projects on urogenital disorders

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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of translational research – human urogenital/reproductive disorders.

  • the pathophysiology of endometriosis (endometrium, endometriosis, macrophage, nerves)

  • mechanisms of uterine physiology and pathology (endometrium, bleeding, menstruation, fibroids)

  • molecular factors affecting sperm production and function (fertility, reproduction, sperm, sex ratio)

  • understanding and treating pregnancy related disorders (pregnancy, preterm labour, parturition, uterus, cervix)

  • vitamin D and immune function (vitamin d, colon, pregnancy, placenta, inflammation)

  • precursor cell therapies for kidney diseases (kidney cell mouse therapy scanning)

  • improving organ function in kidney transplantation (renal, transplant, therapy, regenerative)

  • rodent models of kidney disease (rodent models, kidney disease)

  • the effects of aging on tissue injury and repair (kidney, acute injury, chronic fibrosis)

  • endometrial function and associated disorders (uterus, steroid, inflammation, repair, endometriosis)

  • optimising ovarian tissue transplantation by improving vascularisation (fertility preservation, xenografting, nude mouse, human ovarian tissue, transplantation)

  • mechanism of bladder cancer and translation (Cre-LoxP, carcinogen, FGFR3, CXCR2, cell free DNA)

  • optimisation of drug efficacy and safety in bladder cancer (cancer, chemotherapy, toxicity)

  • pkcα and vascular calcification in kidney dysfunction (PKCα, vascular calcification, chronic kidney disease)

  • decellularised biomaterials for homologous use in urinary bladder auto-augmentation (biomaterial, urinary tract, detrusorotomy, bladder)

  • modelling therapies for renal malformations (kidney, ureter, bladder, malformation, therapy)

  • the causes and treatment of rejection of kidney (alloimunity, inflammation, tissue scarring, kidney disease)

  • biochemical pathways in renal fibrosis (renal, kidney, fibrosis, therapeutic)

  • regenerative medicine therapy for renal injury (regenerative medicine, cell therapy, kidney, injury)

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