Transparency data: Non-tech summaries 2016: projects on cardiovascular system

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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of basic research: cardiovascular, blood and lymphatic system.

  • cellular electrophysiology of cardiac arrhythmias (atrial fibrillation, atrioventricular node, ion channel, myocyte, ventricular tachyarrhythmia)

  • cell mechanisms controlling small blood vessel diameter (arteries, vasodilatation, endothelium, smooth muscle)

  • genetic and pharmacological analysis of thrombosis (bleeding, thrombosis, platelets)

  • examining SLFN14 function in megakaryocytes and platelets (platelets, megakaryocytes, haemostasis, bleeding)

  • genetic and environment effects on heart development (mouse embryo, development, heart, diabetes, hypoxia)

  • image guided therapy for cardiovascular disease (imaging, heart, stroke, ischaemia, therapy)

  • gene cell therapies for ischaemic disease (myocardial infarction, ischaemia, diabetes, stem cells)

  • re-defining the roles of integrins in angiogenesis (angiogenesis, integrins, endothelium)

  • platelet formation and function in thrombosis and repair (platelets, bleeding, thrombosis, regeneration, heart-attack)

  • mechanisms of cardiovascular regeneration (regeneration, epicardium, neovascularisation, vascular protection)

  • the regulation of platelet function as a central mechanism for the control of cardiovascular function and development (platelets, thrombosis, heart attack, stroke, clotting)

  • zebrafish: development, physiology and disease modelling (zebrafish, development, physiology, disease, transgenic)

  • regulation of leukocyte-endothelial interactions (inflamation, atherosclerosis, leukocytes)

  • cardiac remodelling and heart failure (atrial fibrillation, heart failure, ion channel, myocyte, ventricular tachyarrhythmia)

  • morphogenesis during early mammalian development (embryo, congenital defect, cell movement)

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