Transparency data: Non-tech summaries 2016: projects on immune system

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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of basic research, immune system

  • immunity against bacterial and paediatric diseases (vaccines, infectious diseases, paediatrics, bacteria)

  • poxvirus virulence and immunogenicity (immunisation, vaccines, immunology, virus virulence, protein function)

  • development and function of the immune system (lymphocyte, infection, autoimmunity, signalling)

  • genetic and physical control of B cell activation (antibody responses, activation of immune cells, signalling, endocytosis)

  • immunity to ruminant endo- and ecto-parasites (vaccine parasite sheep cattle)

  • salmonella pathogenesis during asymptomatic malaria (malaria salmonella anaemia neutrophil bacteraemia)

  • establishing model for zika infection (zika virus, pathology, immunity)

  • explore the mechanisms of persistence of tertiary lymphoid organs (TLOs) and the relationship with secondary lymphoid organs (tertiary lymphoid structures, salivary glands, immune response, inflammation)

  • inflammatory responses to infection and insult (inflammation, viral infection, immunology)

  • regulation of immune responses (immunity, cell development)

  • bone marrow transplantation: biology and therapy (GVHD, GVT, tumour, leukaemia)

  • identifying new malaria intervention strategies (malaria, plasmodium, genetically modified parasite)

  • mammalian gene control mechanisms and disease (gene regulation, chromatin, triplet repeat disorders, position effect variegation, epigenetics)

  • yô T cells and body surface immunity (yö T-cell immune challenge)

  • immunological memory in transgenic mice (T lymphocyte, virus, tumour, immunity)

  • immune regulation, metabolism and tissue integrity (T cells; environment, autoimmunity, mucosal immunity, metabolism)

  • ZBTB proteins in lymphocyte development (lymphoma)

  • immune cell regulation of epithelial damage and repair (epithelial, repair, T cells, auto-inflammation)

  • molecular mechanisms of T cell mediated immune responses (immune response, autoimmunity, egr, viral infection, tumour)

  • lymphocyte development and antibody repertoire formation (fighting infection, antibodies, ageing, immune response, white blood cells)

  • DNA double-strand break repair, immunity & cancer (DNA repair, cancer, immune system)

  • interactions between mast cells and helminths in inflammatory disease (mast cells, helminths, diabetes, arthritis, cardiovascular disease)

  • complement properdin in immunity and inflammation (properdin, tumour, diet, stimulation)

  • inflammation, cell death and cancer (inflammation, immunity, cancer)

  • translation of the immunological synapse (immunological synapse, tolerogenic DCs, central tolerance, atopic dermatitis, original antigenic sin)

  • immune activation in health and disease (immunity, adjuvants, vaccines, allergy, hypersensitivity)

  • mouse models of chronic inflammatory diseases (cancer, infections, autoimmune disease, pain)

  • tregs in lymphopaenia associated autoimmunity (lymphopaenia, autoimmunity, immunotherapy)

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