Transparency data: Non-tech summaries 2016: projects on nervous system

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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of basic research, nervous system.

  • analysis of neurological mouse mutants (brain, neurodegeneration, psychiatry, behaviour, movement disorders)

  • RNA methylation in neurodevelopmental disorders (rna methylation, synaptic plasticity, fragile-x syndrome, autism, schizophrenia)

  • autoimmune diseases in the central nervous system (multiple sclerosis, autoimmune disease)

  • misfolded proteins in neurodegenerative disease (misfolding, neurodegenerative diseases, proteins)

  • mechanisms underlying neurodegeneration (neurodegeneration, alzheimer’s disease, therapeutic, mechanisms)

  • imaging agents to investigate epileptogenesis (epilepsy, imaging, radiotracer)

  • genes and lifestyle influences on brain ageing (diet, brain, genotype, ageing, inflammation)

  • investigating motor neuron disease and dementia (paralysis, dementia)

  • nervous system injury and repair strategies (hypoxia-ischaemia, neonatal encephalopathy, CNS injury, PNS injury, oxidative stress)

  • development and nervous system repair in zebrafish (brain, spinal cord, injury, regeneration)

  • mechanisms of neuronal dysfunction in neurodegeneration (neuronal function, neurodegeneration, nitric oxide toxicity)

  • brain mechanisms for learning and decision-making (learning, decision-making, prefrontal cortex, reward)

  • development of novel translatable measures and therapeutics for pain disorders (pain, rodents, analgesics, biomarkers, drug discovery)

  • mechanisms of neuronal plasticity (alzheimer’s disease, schizophrenia, synapse, genes)

  • presynaptic function in health and disease (neurotransmitter, neurone, synapse, vesicle, disease)

  • neural plasticity in health and disease (learning, memory, neural development, neurodegeneration)

  • development of new models of FTLD/MND (neurodegeneration; dementia; transgenic; mouse; disease)

  • roles of electrical activity in brain maturation (brain, activity, plasticity, development, olfaction)

  • studies of brain development in the mouse (mouse, brain development)

  • bioelectronic medicines (electrophysiology, implantable devices)

  • tissue isolation for electrophysiology, neurochemistry and pharmacology (neurodegeneration, pain, native, drug discovery)

  • investigation of genetic forms of neurodegeneration (frontotemporal dementia, motor neuron disease, amyotrophic lateral sclerosis, C9orf72)

  • autophagy and neurodegeneration (autophagy, neurodegeneration, ataxia, signalling pathways)

  • inter-connected studies of prion and other neurodegenerative diseases (prions, creutzfeldt-jakob disease, transgenic, therapeutics)

  • cns glial development and demyelinating disease (multiple sclerosis, demyelination, neuroinflammation, neurodegeneration, neuropathology)

  • Mechanisms of synaptic transmission and plasticity in the central nervous system (synaptic transmission, learning and memory, ageing, neurodegeneration)

  • the role of glia in nerve regeneration and cancer (nerves, cancer, regeneration, glia, microenvironment)

  • impact of exercise and NAD levels on brain and fat tissue (voluntary exercise, healthy ageing, epigenetics, NMNAT1, stem cells)

  • dorsal horn circuits in normal and pain states (interneurons; circuits; acute pain; chronic pain; mouse)

  • assessment of vascular cognitive impairment in rodents (dementia, cognition, vascular risk factors, neuroimaging)

  • neural mechanisms of pain and homeostasis (nociception, neuroscience, autonomic nervous system, behaviour)

  • mechanisms of acute and chronic pain (inflammation, arthritis, neuropathy, diabetes, 33. understanding cortical plasticity in health and disease)

  • understanding cortical plasticity in health and disease (memory, schizophrenia, parietal cortex, prefrontal cortex, mouse)

  • triggering and propagation of neurodegeneration (neurodegeneration; parkinson’s disease; ALS; synuclein; RNA-binding proteins)

  • cortico-thalamo-cortical interactions in primate cognition (cortex, thalamus, learning, memory, decision-making)

  • using transplanted neural tissue to understand neurological disease (neuron, development, brain)

  • experimental molecular medicines for restorative neuroimmunology (molecular therapies, inflammation, brain, stem cells, brain repair)

  • mechanisms of brain function and dysfunction (neurons, glia, receptors, glutamate, dopamine)

  • drug development in tuberous sclerosis complex (tuberous sclerosis, drug development, seizures, tumours, cognition)

  • neuron-g lial-pericyte-vascular interactions (neuron, astrocyte, oligodendrocyte, microglia, pericyte)

  • synapses and plasticity in health and disease (alzheimer’s disease; learning & memory; diet; improved mouse models)

  • genome involvement in brain function, disease and development. (disease, genetics, gene regulation, transgenic, mouse)

  • regeneration and cancer in the nervous system (neural stem cells, glioblastoma, tissue environment, injury, repair)

  • establishing connectivity in the brain (brain development, neurodevelopmental disorders, vision)

  • mechanisms underlying huntington’s disease (behaviour, sleep, circadian rhythms, EEG)

  • signalling and neurodegeneration (parkinson’s disease, alzheimer’s disease, disease mechanism, finding new targets for treatment)

  • information encoding for memory storage and retrieval in mammalian brain circuits (brain, memory, perception, alzheimer’s disease)

  • investigating and modulating cortical network activity (dementia, epilepsy, neurons, brain circuits)

  • the function of the neural circuitry of the olfactory bulb (olfactory bulb, smell, neural circuit)

  • information processing in neural networks (brain, neural code, multisensory, perception, memory)

  • preclinical research of novel pain therapeutics (chronic pain, analgesia, hyperalgesia, allodynia, therapeutics)

  • sumoylation accelerates supply-rate depression (epilepsy, SUMOylation, synapsins, levetiracetam)

  • mechanisms of brain plasticity in health and disease (neuron, plasticity, learning, memory)

  • neurogliaform cells in health and disease (interneuron, neocortex, neural circuits, neurogliaform cells, synaptic neurotransmission)

  • mechanisms controlling vertebrate development (neuronal development, axon guidance, vision)

  • organisation and function in cerebellar and pre-cerebellar circuits (cerebellum, movement, learning, neurophysiology, motor control)

  • interactions between the developing visual and nervous system (eye development, brain development, eye disease, sensory guided behaviour)

  • role of gut-brain axis on brain and behaviour (gut-brain, casein, early-life)

  • understanding brain function and dysfunction using stroke models (brain, stroke, blood flow, ageing, MRI)

  • mechanisms underlying neural development (brain, stem cells, neurogenesis, gliogenesis, transcription factors)

  • neural circuit mechanisms for animal behaviour (neuron, brain, cognition, behaviour, navigation)

  • understanding and treating neurodegenerative disorders (neurological diseases, mechanisms of disease, new therapies)

  • molecular determinants of cortical development (cortex, development, neurogenesis, migration, circuits)

  • metabolic and cardiovascular regulation by GLP-1 and the autonomic nervous system (diabetes, obesity, neurophysiology)

  • regulation of the circadian clock and sleep homeostasis (sleep, circadian, clock, neuroscience)

  • cortical structure and information processing (brain, neurons, synapses, neuronal networks, sensory physiology)

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